Parametric bootstrapping for biological sequence motifs
                    
                        
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                    چکیده
منابع مشابه
Parametric inference for biological sequence analysis.
One of the major successes in computational biology has been the unification, by using the graphical model formalism, of a multitude of algorithms for annotating and comparing biological sequences. Graphical models that have been applied to these problems include hidden Markov models for annotation, tree models for phylogenetics, and pair hidden Markov models for alignment. A single algorithm, ...
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Current progress in molecular biology, particularly in genome sequencing and highthroughput technologies, have led to an unprecedented growth in data. The availability of detailed molecular data allows the reconstruction of the structure and dynamic of biological processes and systems. This transition from the molecular level to the systems level is necessary for an understanding of the functio...
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We consider the problem of computing a global alignment between two or more sequences subject to varying mismatch and indel penalties. We prove a tight 3(n=2 )+O(n log n) bound on the worst-case number of distinct optimum alignments for two sequences of length n as the parameters are varied. This re7nes a O(n) upper bound by Gus7eld et al., answering a question posed by Pevzner and Waterman. Ou...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2016
ISSN: 1471-2105
DOI: 10.1186/s12859-016-1246-8